THE TRANSCRIPTOMIC RESPONSE OF CELLS TO A DRUG COMBINATION IS MORE THAN THE SUM OF THE RESPONSES TO THE MONOTHERAPIES

The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

Our ability to discover effective drug combinations is limited, in part by insufficient understanding of how the transcriptional response of two monotherapies results in that of their combination.We analyzed matched time course RNAseq profiling of cells treated with single drugs and their combinations and found that the transcriptional signature of

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Expression of an Efficient Selection Marker Out of a Duplicated Site in the ITRs of a Modified Vaccinia Virus Ankara (MVA)

Background/Objectives: Poxviruses are large DNA viruses that replicate in the host cytoplasm without a Dugout nuclear phase.As vaccine vectors, they can package and express large recombinant cassettes from different positions of their genomic core region.We present a comparison between wildtype modified vaccinia Ankara (MVA) and isolate CR19, which

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